23rd European Symposium on Computer Aided Process Engineering

Design of vascular tree for organ bioprinting

Rodrigo A. Rezende^a, Vladimir Kasyanov^b, Iveta Ozolanta^b, Ken Brakke^c, Jorge V.L. da Silva^a and Vladimir Mironov^a,    ^aDivision ofThree-Dimensional Technologies, Centerfor Information Technology RenatoArcher, Campinas, SP, Brazil, ^bRiga Stradins University, Riga, Latvia, ^cMathematicsDepartment, Susquehanna University, Selinsgrove, PA 17870, USA

Abstract

Organ printing is a variant of the biomedical application of additive manufacturing (rapid prototyping) technology or layer-by-layer additive biofabrication of 3D tissue and organ constructs using self-assembled tissue spheroids as building blocks. Bioengineering of perfusable intraorgan branched vascular trees incorporated into 3D tissue constructs ...