23rd European Symposium on Computer Aided Process Engineering

Mixed integer optimisation of antibody purification processes

Songong Liu^a, Ana S. Simaria^b, Suzanne S. Farid^b and Lazaros G. Papageorgiou^a,    ^aCentre for Process Systems Engineering, Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK, ^bThe Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK

Abstract

Chromatographic operations are identified as critical steps in a monoclonal antibody (mAb) purification process and can represent a significant proportion of the purification material costs. The optimisation of chromatography equipment sizing strategies is therefore crucial to improve the cost-effectiveness ...