May 2021
Beginner
306 pages
6h 20m
English
In my 26 years as a biostatistician at the Rutgers Robert Wood Johnson Medical School in New Jersey, the question I was most frequently asked was, “I’m doing an experiment; how many subjects do I need?” Just about any study, especially one for which you are asking for funding or applying for a grant, will require detailed power and sample size calculations.
As discussed in Chapter 1, the power of a study is the probability that the study will result in a statistically significant finding if the drug or treatment that you are studying is different (hopefully better) than either a placebo or an alternate drug or treatment. For many studies conducted at research labs or universities, powers of 80% ...