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Chapter 16
Example: Gene
Expression Analysis for
Alternative Indications
Scott Spangler, Ignacio Terrizzano,
and Jeffrey Kreulen
P
inhibition of a particular protein in
a cancer cell. Drug companies may create an antibody for one type of
cancer based on the tendency of that type of cancer cell to express a par-
ticular gene. For example, HER-2 is a gene expressed in many breast can-
cers. Monoclonal antibody trastuzumab is eective against certain types
of breast cancer cells that express that gene.
When a drug company has an antibody that is eective against a par-
ticular protein for one type of cancer, they will a ...