
246 ◾ Accele rating D iscover y
Using this approach, we created a graph of all the kinases and then col-
ored them by known P53 associations. e result was immediately striking.
e known P53 kinases were occurring together and the other kinases were
mostly in other areas of the kinase tree. Moreover, there were a few kinases not
known to be P53 kinases that seemed to be in among those that were known.
is was exactly what we hoped to nd, because it gave us a ready list of poten-
tial candidate kinases on which to begin running experiments (Figure22.3).
In order to validate that our predictions were reasonable, we needed to nd
a way to test ...