Chapter One

Metal Ion-Promoted Leaving Group Assistance in the Light Alcohols

R. Stan Brown     Department of Chemistry, Queen's University, Kingston, ON, CanadaE-mail:


Metal ions have numerous roles in promoting the solvolyses of phosphate mono-, di-, and triesters and carboxylate amides, esters, ureas, and carbamates. A little understood role is to promote the departure of a poor nucleofuge formed subsequent to, or concurrent with the addition of a nucleophile to the PO or CO unit. We describe the various mechanisms ...

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