6. C3′-Radical Generation and Reactivity in DNA

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6.1. C3′-Radical Formation Following Irradiation of Transition Metal Coordination Complexes

The C3′-hydrogen exposure to diffusible species is considerably less than hydrogen atoms at the C4′- or C5′-positions (Fig. 1B) and the calculated carbon–hydrogen BDE is surprisingly high given its substitution by a phosphate group (Table 1). In addition, the C3′-hydrogen lies in the major groove of DNA, while most small molecules bind in the minor groove. Consequently, molecules that abstract the C3′-hydrogen atom from DNA are largely confined to coordination compounds. The Barton group has described a number ...

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