3. Equilibrium Macrocylizations

3.1. Ring-Chain Equilibria

JS presented a general theory of ring-chain equilibria as early as 1950.7 Their theory has been extensively used by polymer chemists to describe the cyclic populations of linear polymeric equilibrates in concentrated solutions and in the melt,4042 but for many years the theory has been largely ignored outside the field of polymer chemistry. With the development of macrocyclic chemistry, there has been an increasing interest in the behaviour of mixtures of oligomeric macrocycles under thermodynamic control, and the JS theory was restated to make it more easily understandable and popular,43 to the point that it can now be considered one of the prominent theories in supramolecular chemistry. ...

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