Preface
Introduction
Clinical trials have long been one of the most important tools in the arsenal of clinicians and scientists who help develop pharmaceuticals, biologics, and medical devices. It is reported that nearly 10,000 clinical studies are conducted every year around the world. One can find many excellent books that address fundamental statistical and general scientific principles underlying the design and analysis of clinical trials, such as those by Pocock (1983), Fleiss (1986), Meinert (1986), Friedman, Furberg and DeMets (1996), Piantadosi (1997) and Senn (1997). Numerous references can be found in these fine books.
The aim of this book is unique in that we focus in great detail on a set of selected and practical problems facing ...
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