Chapter 3
Dose-Escalation Methods
Guochen Song (Biogen)
Zoe Zhang (Genentech)
Nolan Wages (University of Virginia)
Anastasia Ivanova (University of North Carolina at Chapel Hill)
Olga Marchenko (QuintilesIMS)
Alex Dmitrienko (Mediana)
3.3 Continual reassessment method
3.4 Partial order continual reassessment method
This chapter gives an overview of dose-finding methods used in early-phase dose- escalation trials with emphasis on oncology trials. It provides a review of basic dose-escalation designs that use rule-based methods. Special attention is given to model-based methods such as the continual reassessment method for trials with a single agent and its extension (partial-order, ...
Get Analysis of Clinical Trials Using SAS, 2nd Edition now with the O’Reilly learning platform.
O’Reilly members experience books, live events, courses curated by job role, and more from O’Reilly and nearly 200 top publishers.
