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Analysis of Clinical Trials Using SAS, 2nd Edition
book

Analysis of Clinical Trials Using SAS, 2nd Edition

by Alex Dmitrienko, Gary G. Koch
July 2017
Intermediate to advanced content levelIntermediate to advanced
410 pages
14h 36m
English
SAS Institute
Content preview from Analysis of Clinical Trials Using SAS, 2nd Edition

Chapter 3

Dose-Escalation Methods

Guochen Song (Biogen)

Zoe Zhang (Genentech)

Nolan Wages (University of Virginia)

Anastasia Ivanova (University of North Carolina at Chapel Hill)

Olga Marchenko (QuintilesIMS)

Alex Dmitrienko (Mediana)

3.1 Introduction

3.2 Rule-based methods

3.3 Continual reassessment method

3.4 Partial order continual reassessment method

3.5 Summary

3.6 References

This chapter gives an overview of dose-finding methods used in early-phase dose- escalation trials with emphasis on oncology trials. It provides a review of basic dose-escalation designs that use rule-based methods. Special attention is given to model-based methods such as the continual reassessment method for trials with a single agent and its extension (partial-order, ...

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Publisher Resources

ISBN: 9781635261448