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Analysis of Clinical Trials Using SAS, 2nd Edition
book

Analysis of Clinical Trials Using SAS, 2nd Edition

by Alex Dmitrienko, Gary G. Koch
July 2017
Intermediate to advanced content levelIntermediate to advanced
410 pages
14h 36m
English
SAS Institute
Content preview from Analysis of Clinical Trials Using SAS, 2nd Edition

Chapter 5

Multiplicity Adjustment Methods

Thomas Brechenmacher (QuintilesIMS)

Alex Dmitrienko (Mediana)

5.1 Introduction

5.2 Single-step procedures

5.3 Procedures with a data-driven hypothesis ordering

5.4 Procedures with a prespecified hypothesis ordering

5.5 Parametric procedures

5.6 Gatekeeping procedures

5.7 References

5.8 Appendix

This chapter discusses statistical strategies for handling multiplicity issues arising in clinical trials with several clinical objectives. It defines commonly used multiplicity adjustments, including basic single-step testing methods, as well as more advanced stepwise methods relying on data-driven or pre-specified hypothesis ordering. The chapter also reviews gatekeeping testing strategies used in more advanced ...

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Publisher Resources

ISBN: 9781635261448