July 2017
Intermediate to advanced
410 pages
14h 36m
English
Alex Dmitrienko (Mediana)
Yang Yuan (SAS Institute)
6.2 Repeated significance tests
6.3 Stochastic curtailment tests
The chapter reviews sequential data monitoring strategies in clinical trials. It introduces a class of group sequential tests (known as repeated significance tests) that are widely used in the assessment of interim findings in late-stage trials. The first part of the chapter provides a detailed review of the process of designing group sequential trials and also discusses flexible procedures for monitoring clinical trial data. The second part of the chapter reviews popular approaches to constructing futility testing procedures in clinical trials. These approaches ...