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Analysis of Clinical Trials Using SAS, 2nd Edition
book

Analysis of Clinical Trials Using SAS, 2nd Edition

by Alex Dmitrienko, Gary G. Koch
July 2017
Intermediate to advanced content levelIntermediate to advanced
410 pages
14h 36m
English
SAS Institute
Content preview from Analysis of Clinical Trials Using SAS, 2nd Edition

Chapter 6

Interim Data Monitoring

Alex Dmitrienko (Mediana)

Yang Yuan (SAS Institute)

6.1 Introduction

6.2 Repeated significance tests

6.3 Stochastic curtailment tests

6.4 References

The chapter reviews sequential data monitoring strategies in clinical trials. It introduces a class of group sequential tests (known as repeated significance tests) that are widely used in the assessment of interim findings in late-stage trials. The first part of the chapter provides a detailed review of the process of designing group sequential trials and also discusses flexible procedures for monitoring clinical trial data. The second part of the chapter reviews popular approaches to constructing futility testing procedures in clinical trials. These approaches ...

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Publisher Resources

ISBN: 9781635261448