Dose-Response Safety Analyses Using Large Health Care Databases
The marginal structural models (MSM) method has been introduced in Chapter 9 in a traditional two-group comparison setting. In this chapter, the application of MSM is demonstrated using a large observational database to assess dose response of a single treatment that’s dynamic over time. The endpoint is mortality, which frequently is the focus of analyses performed using such databases.
While clinical trials in a controlled environment provide ...