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Analysis of Observational Health Care Data Using SAS by Andrew C. Leon, Josep Maria Haro, Robert Obenchain, Douglas E. Faries

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Chapter 13

Dose-Response Safety Analyses Using Large Health Care Databases

Ouhong WangXiang Ling

Abstract

13.1 Introduction

13.2 Data Structure

13.3 Treatment Model and Censoring Model Setup

13.4 Structural Model Implementation

13.5 Discussion

References

 

Abstract

The marginal structural models (MSM) method has been introduced in Chapter 9 in a traditional two-group comparison setting. In this chapter, the application of MSM is demonstrated using a large observational database to assess dose response of a single treatment that’s dynamic over time. The endpoint is mortality, which frequently is the focus of analyses performed using such databases.

 

13.1 Introduction

 

13.1.1 Overview

While clinical trials in a controlled environment provide ...

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