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Anxiety in Children and Adolescents with Autism Spectrum Disorder by Wood Jeffrey J, Philip C. Kendall, Eric A. Storch, Patricia Renno, Connor M. Kerns

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Chapter 4

Neurobiological Mechanisms of Anxiety in ASD

John D. Herrington1,2, Valentina Parma3 and Judith S. Miller1,2,    1The Children’s Hospital of Philadelphia, Philadelphia, PA, United States,    2University of Pennsylvania, Philadelphia, PA, United States,    3Scuola Internazionale Superiore di Studi Avanzati, Trieste, Italy

Abstract

Decades of research on the neurobiology of autism spectrum disorder (ASD) have generally overlooked the importance of co-occurring anxiety. This is surprising, as neurobiological accounts of ASD and anxiety disorders point to highly overlapping systems. This chapter describes the overlap between the neurobiology of anxiety and ASD, with a particular emphasis on amygdala function and structure. As we discuss, ...

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