Modern desktop printers are small technical wonders that can put brilliant, high-resolution images on fine paper for pennies. But for $99 they can’t do everything, including print to the edges of the sheet (a full bleed). Most leave a white border, which is often irregular and differs from printer to printer.
This border can be a big distraction. Its real problem, however, is that the border is undesigned and undesignable.
So what to do? Instead of fighting it, join it. Amplify the white space, and make it part of your designs.