PrologueIntroductionComplex Adaptive SystemsUnderlying PhenomenaWicked ProblemsOverall ApproachCharacterize the Nature of the Wicked ProblemIdentify Anticipated or Experienced Value DeficienciesDetermine What Processes Need to Be Resigned or DesignedEngage Stakeholders in How They Would Proceed with ChangesSynthesize an Integrated Approach Across Contexts and TimeInvolve Stakeholders to Support These Changes, Likely IncrementallySecure and Sustain Resources to Accomplish ChangesExecute Changes, Learning along the Way, and AdaptingHealthCancer ControlOpioid EpidemicCoronavirus PandemicEducationEnergyBattery Electric VehiclesAutonomous VehiclesClimate ChangeTransformationConclusionsEpilogueFurther Reading