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Bioinformatics with R Cookbook by Paurush Praveen Sinha

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Testing data for the Hardy-Weinberg equilibrium

The Hardy-Weinberg Equilibrium (HWE) is a principle stating that the genetic variation in a population will remain constant from one generation to the next in the absence of disturbing factors. When mating is random in a large population with no disruptive circumstances, the law predicts that both genotype and allele frequencies will remain constant because they are in equilibrium. However, mutations, natural selection, nonrandom mating, genetic drift, and gene flow disturb this equilibrium. Any deviation from this equilibrium will thus indicate these phenomena, plus the quality of genotyping. Therefore, performing an HWE test on data can be helpful while analyzing genotypic data. The tests performed ...

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