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Bioprocess Engineering: Basic Concepts, Third Edition by Matthew DeLisa, Fikret Kargi, Michael L. Shuler

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7. Stoichiometry of Microbial Growth and Product Formation

Cell growth and product formation are complex processes reflecting the overall kinetics and stoichiometry of the thousands of intracellular reactions that can be observed within a cell. For many process calculations, we wish to compare potential substrates in terms of cell mass yield, or product yield, or evolution of heat. Also, we may need to know how close the system is operating to its thermodynamic limits. (That is, is product yield constrained by kinetic or thermodynamic considerations?) If a system is close to its thermodynamic limit, it would be unwise to try to improve production through mutation or genetic engineering.

Although the cell is complex, the stoichiometry of conversion ...

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