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Bioprocess Engineering: Basic Concepts, Third Edition by Matthew DeLisa, Fikret Kargi, Michael L. Shuler

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8. How Cellular Information Is Altered

We have discussed some aspects of how cells inherit information and how a chemostat (covered in Chapter 6, “How Cells Grow”) can be used as a tool to select for individual cells with different or augmented metabolism. The mechanism for DNA replication in procaryotes was summarized in Chapter 4, “How Cells Work.” This process is a good example of the exchange of genetic information from one generation to another. However, some individual cells can receive additional genetic information through natural or artificial means. The initial genetic information within a cell may also undergo rearrangements or alterations. In this chapter, we discuss some mechanisms causing alterations in a cell’s genetic information ...

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