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Bioprocess Engineering: Basic Concepts, Third Edition by Matthew DeLisa, Fikret Kargi, Michael L. Shuler

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10. Selection, Scale-Up, Operation, and Control of Bioreactors

Chapter 9, “Operating Considerations for Bioreactors for Suspension and Immobilized Cultures,” focused on idealized descriptions of homogeneous bioreactors with regard to operating mode (batch, fed-batch, continuous, and multistage) and generalized discussions of heterogenous reactors (immobilized cell systems and solid-state fermentation [SSF]). Real processes demand greater insight into the details of reactor configuration. It would be impossible in a book of this type to provide all the information necessary to become a design engineer, but this chapter introduces some of the concepts that drive the choice of real bioreactors. Our focus is primarily on reactors for bacteria and ...

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