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Bioprocess Engineering: Basic Concepts, Third Edition by Matthew DeLisa, Fikret Kargi, Michael L. Shuler

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12. Bioprocess Considerations in Using Animal Cell Cultures

Animal cells have become important catalysts for many bioprocesses. They are capable of making a vast array of important therapeutic proteins. With recombinant DNA techniques, it is possible to achieve significant levels of production of compounds made only in minute amounts in native cells. Animal cells possess the machinery to do complex posttranslational modifications to proteins. This capacity is essential in some cases to the formation of a clinically useful product particularly for therapeutic proteins. Currently, more than 50% of new therapeutic proteins are being produced using mammalian cell tissue culture. Also, the development of stem cell technology opens the possibility ...

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