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Bioprocess Engineering by K Clarke

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11

Downstream processing

Abstract:

Downstream processing of biochemical products requires recovery from a complex mixture of molecules, impurities and contaminants by making use of dedicated unit operations. Each unit operation will bring about a physical change that will alter the product concentration and/or degree of purity. Usually, several unit operations in series are necessary to affect the product specifications.The downstream concentration and purification programme is an integral part of the production process and contributes very significantly to the overall process costs. The actual contribution of the downstream purification programme to the complexity and cost of the entire process depends on the nature of the product and its ...

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