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6
Biosensing Based on Surface-
Enhanced Raman Spectroscopy
Gang Logan Liu, Wenwei Zheng, Pingping Zhang, and Fanqing (Frank) Chen
6.1 Introduction
In view of basic science, to understand biological systems increasingly depends on our
ability to dynamically and quantitatively measure the molecular processes with high sen-
sitivity, speed, exibility, multiplexity, throughput, and reproducibility, usually within
the context of a complex biological and chemical mixture of a tiny amount. A living cell
responds to its changing environment both inside and outside itself in such a dynamic way
that hundreds and thousands of signaling proteins, enzymes, ...