258 Biosensors Based on Nanomaterials and Nanodevices
favorable biomaterial properties. Covalent attachment of biomolecules on NCD is mostly
accomplished using the UV–alkene chemistry (photochemical) and reduction of diazo-
nium salts (electrochemical) or a one-step direct amination using plasmas. The most
important properties for the choice of one of these methods are the identication of
which chemistry yields the best combination of capture yield, selectivity, and stability.
10.4.1 Photochemical Surface Functionalization
Takahashi et al. in 2000 rst introduced a photochemical chlorination/amination/
carboxylation process of the initially H-terminated diamond surface, an important step
toward diamond bio-functionalization. In 2002, Hamers and ...