71Nanomaterial Cell Interactions in Tissue Engineering
been fully harnessed yet to engineer the complex and hierarchical structure of ECM
for engineering tissues, there are big advancements in ECM-like scaffolds toward
engineering tissues. Bottom-up techniques that use small engineered materials to
build complex structures is a promising strategy to solve the limitations associated
with micro/nanofabrication techniques. Mineralized nanobrous scaffolds also hold
promise for engineering different tissues. In future, we can envision that mimicking
microarchitecture of natural tissues by ne processing and creation of ECM-like
nanobrous structures can solve some of the challenges encountered in engineering
of constructs with the aim of achie ...