235Polysaccharide-Based Biomaterials for Cell–Material Interface
Not only chitosan has demonstrated an enhancement on cell differentiation, but
other polysaccharides such as alginate,
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cellulose,
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and methacrylated hyaluronan
also promote cellular differentiation. Alginate-containing PCL nanobers showed
an increase in alkaline phosphatase and mineralization of pre-osteoblastic cells as
compared to PCL only scaffolds.
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Cellulose-containing gelatin nanobers also
improved the osteogenic and adipogenic differentiation of human MSCs.
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Lastly, a
mechanically tunable electrospun nanobrous scaffold prepared from methacrylated
hyaluronan inuenced the differentiation of human MSCs.
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An enhancement in
chondrogenesis was observed on the softer ...