Book description
Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets.- Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research
- Includes detailed presentations of study methodology and data collection, analysis, and interpretation
- Discusses tools like experimental design, sample handling, analytical measurement techniques
Table of contents
- Cover
- List of Contributors
- About the Editors
- Preface
- 1 Introduction to Cellular Signal Transduction
- 2 Mechanisms of Cellular Signal Transduction
-
3 From Cellular Mechanisms to Physiological Responses
- 3.1 Introduction
- 3.2 Cellular Information Flow: Mechanisms of Cellular Signal Integration and Regulation
- 3.3 Crosstalk and Functional Signal Integration in Response to Insulin in Hepatocytes
- 3.4 Systemic Signal Integration
- 3.5 Dysregulation of Insulin Signaling in the Etiology of Type 2 Diabetes
- References
- 4 Signal Transduction in Disease
-
5 Experimental Design in Signal Transduction
- 5.1 Overview of Basic Experimental Design
- 5.2 Aseptic Technique
- 5.3 Biological Sample Collection, Processing, and Pretreatment Technology
- 5.4 Sample Storage
- 5.5 Common In Vitro Studies in Toxicology/Pharmacology
- 5.6 Common In Vivo Studies in Toxicology
- 5.7 Basic Advantages and Disadvantages Associated with Sample Types
- 5.8 Human Epidemiology Studies
- 5.9 Examples of Tox‐ and Pharm‐Based Experiments Relevant to Signal Transduction Endpoints
- 5.10 Coupling Experimental Results Within the Larger Literature Framework to Generate Information
- References
-
6 Techniques for Measuring Cellular Signal Transduction
- 6.1 Introduction
- 6.2 High‐Throughput Versus High‐Content Data
- 6.3 Methods to Measure Signal Transduction Data
- 6.4 Techniques to Generate Large Datasets for Signal Transduction Network Analysis
- 6.5 Bioenergetics
- 6.6 Relating Signaling to Cellular Outcome Using Relevant Assays
- 6.7 Summary
- References
- Suggested Reading
- 7 Computational Methods for Signal Transduction
- 8 A Toxicological Application of Signal Transduction
-
9 Future Research in Signaling
- 9.1 Translational Research and a Spatiotemporal Understanding of Signal Transduction
- 9.2 Integrating Second Messengers into Signal Transduction
- 9.3 Understanding Crosstalk in Signal Transduction
- 9.4 Posttranslational Modifications (PTMs) and Target Identification in Signal Transduction
- 9.5 Epigenetic Endpoints in Signal Transduction
- 9.6 The Integration of Nutrition and Signal Transduction
- References
- Index
- End User License Agreement
Product information
- Title: Cellular Signal Transduction in Toxicology and Pharmacology
- Author(s):
- Release date: April 2019
- Publisher(s): Wiley
- ISBN: 9781119060260
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