V.M. Aris, University of Medicine and Dentistry of New Jersey, USA
Microarrays represent the miniaturization and high throughput serialization of a laboratory assay. There are several types of diverse array technologies currently in use to measure changes in gene expression. In this chapter, we will underscore how to design experiments in order to be able to answer questions posed by the investigator, the different normalization strategies used and their assumptions, the different types of statistical analysis and adjustments for multiple testing, methods of uncovering patterns in the data, and strategies to find meaning in the results.