Chapter 36

Effects of Coffee on Antigen-Specific Immune Responses In Vivo and In Vitro

Masao Goto,  and Yuko Takano-Ishikawa     National Agriculture and Food Research Organization, National Food Research Institute, Tsukuba, Ibaraki, Japan


Coffee is a beverage with potential health benefits, although few studies have focused on its association with allergic responses. The effects of orally administered coffee on allergic responses were investigated using a DO11.10 allergic mouse model. Splenocytes from naïve mice administered coffee showed increased antigen-specific interleukin (IL)-12p40 secretion. When antigen sensitization and coffee administration were performed concurrently, splenocytes exhibited decreased IL-2 and increased IL-12p40 ...

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