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Coffee in Health and Disease Prevention by Victor R. Preedy

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Chapter 47

Coffee and Amyotrophic Lateral Sclerosis

Giorgia Giussani, Elisabetta Pupillo, Paolo Messina,  and Ettore Beghi     Laboratory of Neurological Disorders, Department of Neuroscience, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy

Abstract

Amyotrophic lateral sclerosis (ALS) is a rare, severe, progressive neurological disorder characterized by degeneration of the motor neurons. The etiology of ALS is still unknown. A recent Italian population-based case–control study showed that lifetime coffee intake was less frequent and prolonged among patients with ALS compared to patients with other clinical conditions and to healthy individuals. These findings provide epidemiological evidence of a protective action of coffee ...

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