Coffee-Induced Neural Tube Defects
, Sara De Grazia1,3
, Alberto Vaiarelli2
, and Vittorio Unfer1 1A.G.UN.CO. Obstetrics and Gynecology Center, Rome, Italy 2Reproductive Medicine Unit, University Hospital, Messina, Italy 3R&D Dept. LO.LI Pharma s.r.l, Rome, Italy
The association between caffeine intake and various reproductive problems and developmental malformations has been widely reported, and although a clear consensus has not been reached, several studies correlate its use to many negative effects.
Caffeine intake has been listed among the risk factors for developing neural tube defects (NTDs), a congenital malformation characterized by a multifactorial etiology in which genetic, environmental, ...
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