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Coffee in Health and Disease Prevention by Victor R. Preedy

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Chapter 60

Coffee and Gastrointestinal Glucuronosyltransferases

Christian P. Strassburg,  and Sandra Kalthoff     Department of Medicine I, University Hospital Bonn, Bonn, Germany

Abstract

The beneficial health effects of coffee have, among other mechanisms, been linked to the activation of phase II enzymes, including UDP-glucuronosyltransferases (UGTs). UGTs catalyze the detoxification of many xenobiotic compounds, including human carcinogens and reactive oxygen species. Coffee ingredients like hydroxycinnamic acids were shown to undergo glucuronidation by UGTs. In vitro and in vivo experiments indicate an upregulation of UGT1A activity and transcription, which is dependent on coffee concentration and form of administration. The aryl hydrocarbon ...

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