Chapter 61

Effects of Coffee on Estrogen Sulfation in Human Colon Carcinoma Caco-2 Cells

Hiroomi Tamura     Graduate School of Pharmaceutical Sciences, Keio University, Minato-ku, Tokyo, Japan

Abstract

Recent epidemiological studies have shown that moderate coffee consumption is associated with a lower risk of certain types of cancers, particularly colon cancer in postmenopausal women. To elucidate the molecular basis of the preventive action of coffee toward colon cancer, we focused on the effects of coffee on the metabolism of estrogens by sulfation, a reaction that inactivates estrogens. Estrogens are sulfonated by estrogen sulfotransferase (SULT1E1), and the sulfonated estrogens are reversely hydrolyzed by steroid sulfatase (STS). Sulfonated ...

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