Chapter 66

Protective Effects of Coffee Against Induction of DNA Damage and Cancer by Aflatoxin B1

Franziska Ferk1, Karl Speer2, Miroslav Mišík1, Armen Nersesyan1,  and Siegfried Knasmüller1     1Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria     2Department of Food Chemistry, Technical University of Dresden, Dresden, Germany


Aflatoxin B1 (AFB1) is one of the most potent carcinogens in foods, and it was postulated to account for the prevalence of hepatocellular carcinoma (HCC) in high exposure areas. Epidemiological investigations show that coffee consumption is inversely related to the incidence of HCC and that different molecular mechanisms may cause protective effects. On the basis ...

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