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Coffee in Health and Disease Prevention by Victor R. Preedy

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Chapter 70

Kahweol, a Coffee Diterpene with Anti-inflammatory Properties

Casimiro Cárdenas, Ana R. Quesada,  and Miguel Á. Medina     Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Malaga, Andalusia, Spain

Abstract

Kahweol is an antioxidant diterpene present in coffee beans and unfiltered coffee beverages. Since the mid-2000s, many scientific studies have revealed that kahweol is a multitargeted anti-inflammatory bioactive compound with high potential pharmacological interest. In fact, kahweol is able to inhibit key proinflammatory signals: it inhibits inducible nitric oxide synthase and cyclooxygenase-2 activity and expression, monocyte chemotactic protein-1 secretion, and the expression of adhesion ...

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