Chapter 71

Antifungal Inhibitory Activities of Caffeic and Quinic Acid Derivatives

Jan-Nan Ma,  and Chao-Mei Ma     School of Life Sciences, Inner Mongolia University, Hohhot, Inner Mongolia, China

Abstract

Caffeic acid, quinic acid, and their ester conjugates (caffeoylquinic acids) are the major constituents of coffee. Caffeoylquinic acids and caffeic acid are strong antioxidants with many beneficial effects. These compounds can also be used as starting materials to prepare derivatives with enhanced bioactivities. Notably, some of the derivatives have robust antifungal activities. As systemic fungal infections have increased dramatically in recent years in the immunocompromised population, such as acquired immune deficiency syndrome, cancer, and ...

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