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Coffee in Health and Disease Prevention by Victor R. Preedy

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Chapter 73

Anticancer Effect of Caffeic Acid on Human Cervical Cancer Cells

G. Kanimozhi,  and N.R. Prasad     Department of Biochemistry & Biotechnology, Annamalai University, TN, India

Abstract

Caffeic acid (3,4-dihydroxy cinnamic acid (CA)) is naturally found in coffee, fruits, vegetables and olive oil. It exhibits antioxidant, anti-inflammatory, antiproliferative properties. Caffeic acid has been reported to possess antioxidant property in normal cells and pro-oxidant property in cancer cells. This pro-oxidant-mediated oxidative DNA damage and its downstream signaling induces apoptotic cancer cell death. The aim of this study is to summarize and evaluate the anticancer mechanism of CA in cancer cell lines. CA enhances lipid peroxidative markers ...

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