Chapter 78

Caffeine Cardiovascular Toxicity

Too Much of a Good Thing

Cláudia Deus, Ana F. Branco, Paulo J. Oliveira,  and Vilma Sardão     CNC – Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal


Caffeine is most likely one of the most consumed drug-like molecules in the world. Although a large range of positive effects is associated with caffeine consumption, there is also another side of the coin. Caffeine consumption, especially in susceptible individuals, can trigger cardiovascular events, which can be fatal in some cases. Acute caffeine overconsumption, for example, can increase the incidence of acute myocardial infarction. Also, it has been described that caffeine consumption during pregnancy can alter ...

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