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Coffee in Health and Disease Prevention by Victor R. Preedy

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Chapter 82

Neuroactive β-Carbolines Norharman and Harman in Coffee

Susana Casal     REQUIMTE, Serviço de Bromatologia e Hidrologia, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, Porto, Portugal

Abstract

Coffee is among the highest sources of norharman and harman in the human diet. Their presence in coffee has increased the conflictive and inconclusive list of compounds with possible biological activity in this popular beverage. Because regular coffee consumption has been epidemiologically associated with a reduced risk for Parkinson disease and because the β-carbolines norharman and harman are neuroactive compounds and monoamine oxidase inhibitors, a possible association is appealing to researchers. However, their structural ...

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