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Coffee in Health and Disease Prevention by Victor R. Preedy

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Chapter 100

Caffeic Acid and Organic Anion Transporters hOAT1 and hOAT3

Yuichi Uwai     Department of Pharmaceutics, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan

Abstract

After grapefruit juice was shown to increase the blood concentration of calcium antagonist felodipine orally administered, several kinds of food have been reported to change pharmacokinetics of drugs. At present, functions of drug metabolic enzymes and drug transporters can be evaluated at molecular levels, and food ingredients are commercially available as reagents. Therefore, it is possible to extract the factors responsible for food–drug interaction from in vitro experiments. We performed drug transport experiments using Xenopus laevis oocytes, and found that caffeic ...

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