490 Computational Modelling of Biomechanics and Biotribology
for local uid transport (e.g., nutrient drainage and waste removal) under the
action of an external stimulus.
16.2 Fundamentals of computational mechanobiology
It is well known that the mechanical environment has a major in uence on
the bone regeneration process (McKibbin, 1978). Mechanical stimulation,
in fact, induces bone regeneration or alters its biological pathway. A lim-
ited amount of motion at the bone fracture site has been shown to improve
the healing process (Goodship and Kenwright, 1985); conversely, excessive
movement may cause the opposite effect (Einhorn, 1995). Current chal-
lenges involve the determination of the appropriate mechanical stimulants
to promote ...