Finite element modelling of bone tissue scaffolds 507
fractured trabecular bone. The micro-scale model, in turn, was utilized to
predict the local patterns of tissue differentiation within the fracture site and
then how the equivalent mechanical properties of the macro-scale model
change with time. The spatial and temporal patterns of tissue differentia-
tion predicted by this model (Fig. 16.12c) were in general agreement with
those observed experimentally (Diamond et al. , 2007). Such approaches will
be translated into the clinical side with the development of patient-speci c
multi-scale studies (Kerckhoffs et al. , 2008).
16.5 Conclusions and future trends
Bone tissue engineering is an emerging multidisciplinary eld that, besides ...