
118 Computational Modelling of Biomechanics and Biotribology
This model was originally developed to account for experimental varia-
tions in the sizes of cells seeded on substrates or matrices of different rigid-
ities (Fig. 4.14), and was used to evaluate the average cell orientation, the
mean polarization stress, and the effective elastic constants of the material
(Zemel et al ., 2006). This model has the ability to predict the monotonic
increase in cellular forces with increases to matrix rigidity in one-, two-, or
three-dimensional simulations, as well as it is also able to predict the align-
ment of stress bers parallel to the long axis ...