164 Computational Modelling of Biomechanics and Biotribology
5.5 Mechanics at cellular scale: a submodeling
approach
A challenging and unsolved task is represented by the identi cation and
explanation of the correlation among the external mechanical stimuli
applied to organs and both microscale tissue homeostasis and remodeling
mechanisms (Lavagnino and Arnoczky, 2005; Ingber, 2008). It is well known
that mechanical stimuli induce a cellular biological response characterized
by the activation of both catabolic and anabolic processes by means of a cas-
cade of gene expressions. In turn, these processes depend on local mechan-
otransduction ...
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