channels beneath the myelin sheath do not contribute to action
potential generation at the paranodal and internodal segments along
the fi bre length. These ionic channels are insensitive to the short-
duration current stimuli in simulated demyelinating neuropathies
(CMT1A, CIDP, CIDP subtypes, GBS and MMN).
Mechanisms Defi ning the Action Potential Abnormalities in
Simulated ALS
The action potential changes in the simulated cases of ALS1, ALS2
and ALS3 (Fig. 5, third column) are determined by the kinetics of
the currents (Fig. 8), which are compared to those in the normal
case. The investigated current kinetics of the action potentials in the
three simulated ALS cases, is presented in the same manner as in
Fig. 6, i.e., the shown currents ar ...