
(CIDP) and PISD (CIDP subtypes). The contribution of nodal ionic
channels to the total ionic currents (I
i
, dotted line) is negligible in
the normal and abnormal cases (Fig. 13a). In the paranodal and
mid-internodal segments, the internodal slow potassium (I
Ks
)
currents, in the normal and ISD cases, dominate in the total ionic
currents (Fig. 13b,c). However, the activated inward rectifi er (IR),
leak (L
k
) and internodal slow potassium channels, in the PSD and
Fig. 14. During the subthreshold hyperpolarizing current stimuli (–40% of the
threshold), the kinetics of the transaxonal (I
a
, dotted lines) and external membrane
(I
m
, continuous lines) currents ...