
78 Computational Neuroscience: Simulated Demyelinating Neuropathies and Neuronopathies
Fig. 27. The temporal distributions of action potentials (V) and their corresponding
extracellular potentials (P) in the normal, mild ISD, PSD, PISD (fi rst panel),
severe IFD, PFD, PIFD (second panel), ALS1, ALS2 and ALS3 (third panel) cases
are presented for human motor nerve fi bers. The action potentials are simulated
by adding long-lasting depolarizing stimuli, which correspond to 1.1 times the
threshold for a 1 ms current stimulus. The potentials are at each node from the
7th to 14th. However, each node behaves identically in the normal, systematically ...