104 Computational Neuroscience: Simulated Demyelinating Neuropathies and Neuronopathies
layer (R
pa
) defi nes the equivalent periaxonal layer (R
pa
*) [see Fig. 1 on
page 19], which assists action potential propagation. The periaxonal
resistance in the case without aqueous layers is higher (R
pa
, 300 MΩ,
Table 3) than the equivalent periaxonal resistance. Consequently, the
decrease of the paranodal seal resistance in the cases with aqueous
layers results in an edditional increase of the longitudinal current
fl ow through the paranodal axolemma to the periaxonal space. As
a result, conduction velocities of action potentials are additionally
increased in the simulated CIDP cases.
A signifi cantly higher effect of the aqueous layers is obtained
on the ...