
18 Computational Pharmacokinetics
which we can compute from the observed plasma concentration curve. In
what follows it is important to distinguish between MRT, which is the true
mean residence time, and MRT
app
which is a computable number from plasma
concentrations. The latter can also be computed when the administration is
not a bolus dose, but it is only when it is a bolus dose that it estimates the
true mean residence time. The relationship between MRT and MRT
app
will
be further discussed later in this book.
In the notational jungle around MRT, let us introduce one further nota-
tion. We let MRT
iv
stand for the apparent MRT after a bolus dose. Thus ...