Skip to Main Content
Computational Pharmacokinetics
book

Computational Pharmacokinetics

by Anders Kallen
July 2007
Intermediate to advanced content levelIntermediate to advanced
184 pages
5h 30m
English
Chapman and Hall/CRC
Content preview from Computational Pharmacokinetics
Empirical pharmacokinetics 23
Box 2.1 Direct derivation of the convolution equation
We will here do a derivation of equation 2.12 from first principles, in order
to highlight the underlying assumptions. Concentrations are assumed to be
given in mg/L.
Assume that we give a unit bolus dose at time s, the plasma concentration
at time t>sis given by G(t, s). The mathematical linearity of the system
then implies that if the dose instead is D mg, the plasma concentration at
time t is DG(t, s). Consider a small interval (s, s s), during which there is
approximately a(ss mg of drug absorbed. Its contribution to C(t)isthen
given by G(t, s)a(ss, and the
Become an O’Reilly member and get unlimited access to this title plus top books and audiobooks from O’Reilly and nearly 200 top publishers, thousands of courses curated by job role, 150+ live events each month,
and much more.
Start your free trial

You might also like

Biomolecular and Bioanalytical Techniques

Biomolecular and Bioanalytical Techniques

Vasudevan Ramesh

Publisher Resources

ISBN: 9781420060669